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| Id: | 23739
| | Autor: | Moraes Braga, Anna Carolina de; Reason, Iara J. Messias; Maluf, Eliane Cesario Pereira; Vieira, Elizabete Regina
| | Título: | Leprosy and confinement due to leprosy show high association with hepatitis C in Southern Brazil
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| | Fonte: | s.l; s.n; 2006. 6 p. .
| | Resumo: | Leprosy is a disease, which is accompanied by cellular immunity defects, which may increase the susceptibility of patients in developing co-infections. The association of leprosy with hepatitis C virus (HCV) infection, human immunodeficiency virus types 1 and 2 (HIV 1+2) infection and human T-lymphotropic virus types I and II (HTLV I+II) infection have previously been described in different populations. In this study, the prevalence of these infections was determined in 199 Southern Brazilian leprosy patients and in 681 matched controls. Antibodies to HCV were positive in 3.52% of the patients (7/199) and in 0.15% of the controls (1/681; odds ratio (OR)=24.79; 95% CI=3.03-202.74; p=0.0002). An increased risk of HCV infection was observed in institutionalized patients (OR=14.95; 95% CI=1.76-127.03; p=0.004) and in the lepromatous form of the disease (OR=7.67; 95% CI=0.43-136.62; p=ns). Anti-HIV 1+2 antibodies were positive in only one out-patient (1/199; 0.50%) and in none of the controls (0/681; OR=3.43; 95% CI=0.21-55.16; p>0.05). No leprosy patient was positive for anti-HTLV I+II antibodies. These results demonstrate an increased prevalence of HCV infection in leprosy patients from South Brazil and that both institutionalization and lepromatous form of the disease confer higher risk to HCV infection. These data emphasizes the importance of monitoring hepatitis C and leprosy interactions and the need of special care to institutionalized and lepromatous patients in preventing HCV co-infection. (AU).
| | Descritores: | Brasil/EP
Infecções por HIV/CO/EP
Infecções por HTLV-I/CO/EP
Infecções por HTLV-II/CO/EP
Hepacivirus/IM
Hepatite C/*CO/*EP
Anticorpos Anti-Hepatite C/BL
Hanseníase/*CO/*EP
Isolamento de Pacientes/*
Prevalência
| | Limites: | Masculino
Meia-Idade
Humanos
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
| | Localização: | BR191.1; 09359/S |
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